Thrombotic Microangiopathies and DIC

A 30-year-old female with altered mental status and irritability for 4 days, presented with a temperature of 103°F, pallor, and bruising on her arms, along with a feverish sensation. Her complete blood count (CBC) reveals a hemoglobin level of 8 g/L, a white blood cell count of 15,000, and a platelet count of 70,000. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are within normal limits. Creatinine is 1.7 mg/dl. She has a history of a spontaneous vaginal delivery 15 days ago, and her condition is progressively deteriorating.

A patient presented with febrile illness and an altered state of consciousness. On examination, he had a GCS of 12 and a fever of 101. investigations showed

• Hb: 10 g/L
• Platelets: 50,000
• LDH: 3500
• PT, APTT: Normal
• Peripheral film: normocytic and normochromic anemia, schistocytes. 

What is the most appropriate treatment option for this patient?

The patient has recently been diagnosed with thrombotic thrombocytopenic purpura (TTP), and plasmapheresis was recommended but is currently unavailable. What immediate treatment should be provided?

A newly diagnosed case of TTP is being treated with plasmapheresis. How to monitor the response?

A patient who was previously diagnosed with TTP and showed significant improvement following plasma exchange was discharged. After two months, he has experienced a recurrence of TTP. How should they be treated in this recurrent episode?

A patient with fever, altered consciousness, renal dysfunction, and anemia is suspected to have TTP. Which of the following features may be suggestive of TTP?

A 50-year-old female with a febrile illness following the development of a diabetic foot ulcer presents with a hemoglobin level of 10.5 g/dL and a white blood cell count of 22,000/mm³. Her BT (bleeding time) is 27 seconds, and her PTT (partial thromboplastin time) is 62 seconds. The patient has no reported history of bleeding. What is the most appropriate next step in her management?

A patient presented with a febrile illness and a productive cough. His initial investigations were suggestive of disseminated intravascular coagulation. Which of the following is the most specific test for its diagnosis?

A patient was admitted to the Intensive Care Unit and has developed DIC. How can we check its severity?

A patient became unconscious after a road traffic accident and was admitted to the neurosurgery ICU. The patient had a good recovery until he developed DIC after changing his antibiotics. Which of the following drugs is responsible for the development of DIC?