Factor Deficiencies

A young male has developed uncontrolled bleeding after a tooth extraction. Investigations are done, which are as follows
• WBC: 6000
• Platelets: 250000
• Hemoglobin: 14 g/L
• PT: 13 sec
• APTT: 48 Sec
• BT: 13 minutes (control <10 minutes)
What is the diagnosis?

A 14-year-old boy with a history of recurrent epistaxis underwent investigations, which revealed normal prothrombin time (PT) and activated partial thromboplastin time (aPTT), but an 11-minute bleeding time. Additional testing indicated reduced primary platelet aggregation and a normal response to Ristocetin. What is the diagnosis in this case?

A 50-year-old female presented with complaints of pain and swelling of the left arm and epistaxis. She also gave a history of easy bruising from the previous 01 months. On examination, she has 4 cm of woody swelling with tenderness on the lateral aspect of the arm. Bruises are visible on both upper and lower limbs. There is no clinical evidence of anemia or edema. although she has mild jaundice She has no history of bleeding in the past and has never been admitted to a hospital nor received prolonged treatment for any illness. Her investigations are as follows
• Hb: 10.5 g/dL (MCV: 85 fl),
• WBC: 10,000
• Platelets: 190000
• PT: 13 s (control 13 s)
• aPTT 45 s (control 45 s)
• Bleeding time: 13 minutes (control <10 minutes)
What is the most probable diagnosis?

A patient was diagnosed with von Willebrand disease. Its classification is based on which factors?

The patient presented to OPD as a diagnosed case of Von Willebrand, and investigations showed thrombocytopenia. It is associated with which of the type of von Willebrand disease?

A patient was diagnosed with von Willebrand disease associated with thrombocytopenia. How will you treat it?

A consultation call was received from the oral and maxillofacial surgery (OMFS) department regarding a patient with a confirmed diagnosis of von Willebrand disease who is scheduled for a tooth extraction. What advice should be given in this situation?

A patient presented with acquired von Willebrand syndrome. Which of the following is not associated with it?

A newborn in the nursery is experiencing persistent bleeding from the umbilical cord stump, and the mother has informed that the baby’s siblings also have a history of bleeding tendencies. What tests should be conducted in this situation?

A young boy presented with knee swelling and was later diagnosed with hemophilia A. What is the most prevalent genetic cause of this condition?

A recently diagnosed young patient with hemophilia A arrived at the emergency department, complaining of pain and swelling in his right knee. Upon examination, the affected knee exhibited pain, limited mobility, and swollen significantly. The patient’s weight is 35 kg. How should this patient be managed?

A 2-year-old boy was transferred to the surgical department from a local hospital following circumcision and persistent bleeding. Investigations revealed normal platelet counts, normal bleeding time, a prothrombin time (PT) of 12 seconds, and an activated partial thromboplastin time (APTT) of 70 seconds. What is the diagnosis in this case?

A 60-year-old female diagnosed with rheumatoid arthritis for the previous 15 years came to the gynecology outpatient department due to vaginal bleeding. Investigative tests revealed normal findings for ultrasound of the pelvis, platelet counts, bleeding time, and prothrombin time (PT), but an extended activated partial thromboplastin time (aPTT). Furthermore, mixing studies failed to correct the prolonged aPTT. What is the diagnosis in this case?

A young boy has been diagnosed with severe hemophilia and requires treatment for a muscle hematoma. However, factor VIII concentrate is unavailable. How should he be managed in this situation?

The ENT department has made a consultation request for a planned tonsillectomy in a young girl. However, her aPTT is recorded at 85 seconds incidentally, while the prothrombin time is normal. The aPTT corrects when mixed with plasma. What diagnosis can be inferred from these findings?