Inherited and Acquired Thrombophilia

A patient presented with DVT after taking oral contraceptive pills for 1 month. Which of the following thrombophilias has an increased risk of VTE with the use of OCPs?

A 30-year-old female was taking oral contraceptive pills for contraception. She came to OPD with concern that she may develop thrombosis as her maternal aunt is going through treatment with anticoagulation for a similar problem. Her aunt’s thrombophilia screening was positive for factor V Leiden mutation. What will you advice?

A young female taking oral contraceptive pills developed shortness of breath, palpitations, and cyanosis after air travel. On examination, she is tachycardiac and tachypneic, with a blood pressure of 110/70 mmHg and loud P2, and vesicular breathing on chest examination. Investigations showed

• Chest X-ray: normal
• ABGs: Respiratory alkalosis with hypoxemia
• Factor V Leiden mutation: Heterozygous

What is the most appropriate treatment for her?

The patient has a history of two unprovoked thrombosis episodes, and in the third episode, despite being advised to take heparin, he developed DVT. What could be the potential underlying cause in this case?

A young female who was initially treated for deep vein thrombosis with warfarin has now returned with skin purpura, and her INR is within the target range. What might be the underlying cause of this issue?

A patient has a history of recurrent thrombosis, with involvement of both arterial and venous systems. Which of the following could be the cause?

A patient had a history of arthritis and now developed DVT of the right leg. Labs were done which showed PT of 14 seconds and APTT is 70 Seconds. Mixing studies did not correct the APTT. What is the diagnosis?