Hemolysis MCQs

A male patient developed a fever, and investigations revealed he had Plasmodium vivax malaria. He was treated with primaquine and other antimalarials. After a few days, he presented with jaundice and pallor. Further investigations showed

• Hemoglobin: 8.7 g/dL
• Peripheral blood film: Normochromic and normocytic picture and bite cells
• Bilirubin level: 4.27 mg/dL
• ALT: 27 U/L
• Alkaline phosphatase: 110 U/L
• G6PD levels:  normal

What is the likely diagnosis in this case?

A middle-aged male has presented with complaints of fatigue and lethargy. On examination, he appears pale and has moderate jaundice. Laboratory investigations reveal a hemoglobin (Hb) level of 8.9 g/dL, and a peripheral blood film demonstrates 4% fragmented red blood cells (RBCs). Which of the following is not a diagnosis?

A patient presents with symptoms of anemia, jaundice, and splenomegaly, raising suspicion of intravascular hemolysis. Which diagnostic test would be the most specific for confirming this condition?

A middle-aged woman came to OPD with joint pain and swelling in multiple joints, recurrent oral ulcers, and significant hair loss over the past month. She has now also developed severe fatigue and pallor. Her initial investigations reveal a hemoglobin level of 7.6. What would be the most appropriate way to evaluate the cause of anemia?

A 40-year-old male has been experiencing a fever for one week and a productive cough for five days. His investigations indicate a hemoglobin level of 9.7 g/dL, an elevated LDH level, and a reticulocyte count of 6%. A chest X-ray reveals a consolidation patch, and upon examination, he exhibits a skin rash with target-like lesions. What is the likely underlying cause of the anemia?

Splenectomy was planned for different patients in the general surgery department. Which of the following is the most helpful to address the underlying cause?

A 30-year-old woman presented with abdominal pain and was incidentally discovered to have cholelithiasis. Her hemoglobin (Hb) level is 10, and her mean corpuscular hemoglobin concentration (MCHC) is elevated. Physical examination revealed splenomegaly. Her reticulocyte count is 9%, and the Coombs test is negative. What is the likely diagnosis in this case?

A patient presented with frequent episodes of dark-colored urine and difficulty in swallowing. Laboratory results show a hemoglobin (Hb) level of 8.9 g/dL, and a reticulocyte count is 9%. He also said that he has been prescribed to take blood thinners lifelong due to prior episodes of deep vein thrombosis (DVT). What is the most suitable diagnostic investigation to confirm the diagnosis in this case?